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The principal cytochrome P450 isoenzyme associated appears to get CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. Close to 85% of the oral dose seems during the urine within just 24 hrs of administration, most since the glucuronide conjugate, with modest quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity info.Opioids